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Sulfonated inhibitors of the RNA editing ligases validate the essential role of the MRP1/2 proteins in kinetoplastid RNA editing

The RNA editing core complex (RECC) catalyzes mitochondrial U-insertion/deletion mRNA editing in trypanosomatid flagellates. Some naphthalene-based sulfonated compounds, such as C35 and MrB, competitively inhibit the auto-adenylylation activity of an essential RECC enzyme, kinetoplastid RNA editing...

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Bibliografski detalji
Izdano u:RNA
Glavni autori: Mehta, Vaibhav, Moshiri, Houtan, Srikanth, Akshaya, Kala, Smriti, Lukeš, Julius, Salavati, Reza
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297121/
https://ncbi.nlm.nih.gov/pubmed/32276989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.075598.120
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