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Structural Insights into the Activation of mTORC1 on the Lysosomal Surface
Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regul...
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| Publicado en: | Trends Biochem Sci |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7297057/ https://ncbi.nlm.nih.gov/pubmed/32311329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2020.02.004 |
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