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Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
The mechanistic target of rapamycin (mTOR) signal-transduction pathway plays a key role in regulating many aspects of metabolic processes. The central player of the mTOR signaling pathway, mTOR complex 1 (mTORC1), is recruited by the pentameric Ragulator complex and the heterodimeric Rag GTPase comp...
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| Udgivet i: | Cell Discov |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5742854/ https://ncbi.nlm.nih.gov/pubmed/29285400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2017.49 |
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