Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Immune evasion is a major obstacle for cancer treatment. Common mechanisms include impaired antigen presentation through mutations or loss of heterozygosity (LOH) of the major histocompatibility complex class I (MHC-I), which has been implicated in resistance to immune checkpoint blockade (ICB) ther...

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Udgivet i:Nature
Main Authors: Yamamoto, Keisuke, Venida, Anthony, Yano, Julian, Biancur, Douglas E., Kakiuchi, Miwako, Gupta, Suprit, Sohn, Albert S.W., Mukhopadhyay, Subhadip, Lin, Elaine Y., Parker, Seth J., Banh, Robert S., Paulo, Joao A., Wen, Kwun Wah, Debnath, Jayanta, Kim, Grace E., Mancias, Joseph D., Fearon, Douglas T., Perera, Rushika M., Kimmelman, Alec C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296553/
https://ncbi.nlm.nih.gov/pubmed/32376951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2229-5
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