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Mapping the Molecular Surface of the Analgesic Na(V)1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions
[Image: see text] Compelling human genetic studies have identified the voltage-gated sodium channel Na(V)1.7 as a promising therapeutic target for the treatment of pain. The analgesic spider-venom-derived peptide μ-theraphotoxin-Pn3a is an exceptionally potent and selective inhibitor of Na(V)1.7; ho...
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| Publicat a: | ACS Pharmacol Transl Sci |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American
Chemical Society
2020
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7296542/ https://ncbi.nlm.nih.gov/pubmed/32566918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00002 |
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