Mapping the Molecular Surface of the Analgesic Na(V)1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions

[Image: see text] Compelling human genetic studies have identified the voltage-gated sodium channel Na(V)1.7 as a promising therapeutic target for the treatment of pain. The analgesic spider-venom-derived peptide μ-theraphotoxin-Pn3a is an exceptionally potent and selective inhibitor of Na(V)1.7; ho...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Mueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R., Vetter, Irina
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296542/
https://ncbi.nlm.nih.gov/pubmed/32566918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00002
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados