Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of Na(V)1.7-Mediated Pain

Loss-of-function mutations of Na(V)1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of Na(V)1.7 a promising therapeutic strategy for the treatment of pain. We cha...

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Udgivet i:Toxins (Basel)
Main Authors: Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J., Vetter, Irina
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810223/
https://ncbi.nlm.nih.gov/pubmed/26999206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins8030078
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