GpTx‐1 and [Ala(5), Phe(6), Leu(26), Arg(28)]GpTx‐1, two peptide Na(V)1.7 inhibitors: analgesic and tolerance properties at the spinal level

BACKGROUND AND PURPOSE: The voltage‐gated sodium channel Na(V)1.7 is considered a therapeutic target for pain treatment based on human genetic evidence. GpTx‐1 and its potent analogue [Ala(5), Phe(6), Leu(26), Arg(28)]GpTx‐1 (GpTx‐1‐71) were recently characterized as Na(V)1.7 inhibitors in vitro. Fu...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Chen, Chao, Xu, Biao, Shi, Xuerui, Zhang, Mengna, Zhang, Qinqin, Zhang, Ting, Zhao, Weidong, Zhang, Run, Wang, Zilong, Li, Ning, Fang, Quan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151339/
https://ncbi.nlm.nih.gov/pubmed/30076786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14461
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