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Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

Polyglutamine spinocerebellar ataxias (polyQ SCAs) include SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17 and constitute a group of adult onset neurodegenerative disorders caused by the expansion of a CAG repeat sequence located within the coding region of specific genes, which translates into polyglutamin...

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Détails bibliographiques
Publié dans:Front Neurosci
Auteurs principaux: Niewiadomska-Cimicka, Anna, Hache, Antoine, Trottier, Yvon
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296114/
https://ncbi.nlm.nih.gov/pubmed/32581696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00571
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