Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer

PURPOSE: Survivin (BIRC5) is a promising tumor biomarker. Conflicting data exist on its prognostic effect in breast cancer. These data may at least be partly due to the manual interpretation of immunohistochemical staining, especially as survivin can be located in both the nucleus and cytoplasm. Qua...

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Pubblicato in:Clin Cancer Res
Autori principali: Brennan, Donal J., Rexhepaj, Elton, O’Brien, Sallyann L., McSherry, Elaine, O’Connor, Darran P., Fagan, Ailís, Culhane, Aedín C., Higgins, Desmond G., Jirstrom, Karin, Millikan, Robert C., Landberg, Goran, Duffy, Michael J., Hewitt, Stephen M., Gallagher, William M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295090/
https://ncbi.nlm.nih.gov/pubmed/18451232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1760
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