Caenorhabditis elegans Lipin 1 moderates the lifespan‐shortening effects of dietary glucose by maintaining ω‐6 polyunsaturated fatty acids

Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood. Here, we show that Lipin 1/LPIN‐1, a phosphatidic acid phosphatase and a putative transcriptional coregulator, prevents life‐shortening effects...

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Publicado en:Aging Cell
Autores principales: Jung, Yoonji, Kwon, Sujeong, Ham, Seokjin, Lee, Dongyeop, Park, Hae‐Eun H., Yamaoka, Yasuyo, Jeong, Dae‐Eun, Artan, Murat, Altintas, Ozlem, Park, Sangsoon, Hwang, Wooseon, Lee, Yujin, Son, Heehwa G., An, Seon Woo A., Kim, Eun Ji E., Seo, Mihwa, Lee, Seung‐Jae V.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294780/
https://ncbi.nlm.nih.gov/pubmed/32475074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13150
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