Caenorhabditis elegans Lipin 1 moderates the lifespan‐shortening effects of dietary glucose by maintaining ω‐6 polyunsaturated fatty acids

Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood. Here, we show that Lipin 1/LPIN‐1, a phosphatidic acid phosphatase and a putative transcriptional coregulator, prevents life‐shortening effects...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Jung, Yoonji, Kwon, Sujeong, Ham, Seokjin, Lee, Dongyeop, Park, Hae‐Eun H., Yamaoka, Yasuyo, Jeong, Dae‐Eun, Artan, Murat, Altintas, Ozlem, Park, Sangsoon, Hwang, Wooseon, Lee, Yujin, Son, Heehwa G., An, Seon Woo A., Kim, Eun Ji E., Seo, Mihwa, Lee, Seung‐Jae V.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294780/
https://ncbi.nlm.nih.gov/pubmed/32475074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13150
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