Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop

A hallmark of aging is immunosenescence, a decline in immune functions, which appeared to be inevitable in living organisms, including Caenorhabditis elegans. Here, we show that genetic inhibition of the DAF-2/insulin/IGF-1 receptor drastically enhances immunocompetence in old age in C. elegans. We...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Lee, Yujin, Jung, Yoonji, Jeong, Dae-Eun, Hwang, Wooseon, Ham, Seokjin, Park, Hae-Eun H., Kwon, Sujeong, Ashraf, Jasmine M., Murphy, Coleen T., Lee, Seung-Jae V.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941181/
https://ncbi.nlm.nih.gov/pubmed/33666644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006174
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