Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

[Image: see text] B-cell lymphoma 6 (BCL6) is a transcriptional repressor frequently deregulated in lymphoid malignancies. BCL6 engages with number of corepressors, and these protein–protein interactions are being explored as a strategy for drug development. Here, we report the development of an irr...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Teng, Mingxing, Ficarro, Scott B., Yoon, Hojong, Che, Jianwei, Zhou, Jing, Fischer, Eric S., Marto, Jarrod A., Zhang, Tinghu, Gray, Nathanael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294706/
https://ncbi.nlm.nih.gov/pubmed/32551010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00111
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