FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

The IgG Fc domain has the capacity to interact with diverse types of receptors, including the neonatal Fc receptor (FcRn) and Fcγ receptors (FcγRs), which confer pleiotropic biological activities. Whereas FcRn regulates IgG epithelial transport and recycling, Fc effector activities, such as antibody...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Borghi, Sara, Bournazos, Stylianos, Thulin, Natalie K., Li, Chao, Gajewski, Anna, Sherwood, Robert W., Zhang, Sheng, Harris, Eva, Jagannathan, Prasanna, Wang, Lai-Xi, Ravetch, Jeffrey V., Wang, Taia T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293622/
https://ncbi.nlm.nih.gov/pubmed/32461366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004325117
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