FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

The IgG Fc domain has the capacity to interact with diverse types of receptors, including the neonatal Fc receptor (FcRn) and Fcγ receptors (FcγRs), which confer pleiotropic biological activities. Whereas FcRn regulates IgG epithelial transport and recycling, Fc effector activities, such as antibody...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Borghi, Sara, Bournazos, Stylianos, Thulin, Natalie K., Li, Chao, Gajewski, Anna, Sherwood, Robert W., Zhang, Sheng, Harris, Eva, Jagannathan, Prasanna, Wang, Lai-Xi, Ravetch, Jeffrey V., Wang, Taia T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293622/
https://ncbi.nlm.nih.gov/pubmed/32461366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004325117
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