A Recombinant Immunotoxin Targeting CD22 With Low Immunogenicity, Low Nonspecific Toxicity, and High Antitumor Activity in Mice

Recombinant immunotoxins (RITs) are genetically engineered proteins designed to kill cancer cells. The RIT HA22 contains the Fv portion of an anti-CD22 antibody fused to a 38 kDa fragment of Pseudomonas exotoxin A (PE38). As PE38 is a bacterial protein, patients frequently produce antibodies that ne...

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Detaylı Bibliyografya
Yayımlandı:J Immunother
Asıl Yazarlar: Hansen, Johanna K., Weldon, John E., Xiang, Laiman, Beers, Richard, Onda, Masanori, Pastan, Ira
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291874/
https://ncbi.nlm.nih.gov/pubmed/20445350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181cd1164
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