The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells

3-bromopyruvate (3-BP) is a small molecule with anticancer and antimicrobial activities. 3-BP is taken up selectively by cancer cells’ mono-carboxylate transporters (MCTs), which are highly overexpressed by many cancers. When 3-BP enters cancer cells it inactivates several glycolytic and mitochondri...

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Publicado en:Cells
Main Authors: Cal, Magdalena, Matyjaszczyk, Irwin, Litwin, Ireneusz, Augustyniak, Daria, Ogórek, Rafał, Ko, Young, Ułaszewski, Stanisław
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290944/
https://ncbi.nlm.nih.gov/pubmed/32397119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051161
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