Age Mosaicism across Multiple Scales in Adult Tissues

Most neurons are not replaced during an animal’s lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins. To study the lifespans of cells and proteins in adult tissues, we combined isotope labeling of mice with a hybrid imaging meth...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Arrojo e Drigo, Rafael, Lev-Ram, Varda, Tyagi, Swati, Ramachandra, Ranjan, Deerinck, Thomas, Bushong, Eric, Phan, Sebastien, Orphan, Victoria, Lechene, Claude, Ellisman, Mark H., Hetzer, Martin W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289515/
https://ncbi.nlm.nih.gov/pubmed/31178361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.05.010
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