Polarized epidermal growth factor secretion ensures robust vulval cell fate specification in Caenorhabditis elegans

The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate. The EGF receptor in the nearest VPC sequesters the limiting EGF amounts released by the AC to prevent EGF from spreading to distal VPCs. Here, we...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Development
Prif Awduron: Mereu, Louisa, Morf, Matthias K., Spiri, Silvan, Gutierrez, Peter, Escobar-Restrepo, Juan M., Daube, Michael, Walser, Michael, Hajnal, Alex
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286359/
https://ncbi.nlm.nih.gov/pubmed/32439759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.175760
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