Polarized epidermal growth factor secretion ensures robust vulval cell fate specification in Caenorhabditis elegans

The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate. The EGF receptor in the nearest VPC sequesters the limiting EGF amounts released by the AC to prevent EGF from spreading to distal VPCs. Here, we...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Development
Main Authors: Mereu, Louisa, Morf, Matthias K., Spiri, Silvan, Gutierrez, Peter, Escobar-Restrepo, Juan M., Daube, Michael, Walser, Michael, Hajnal, Alex
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286359/
https://ncbi.nlm.nih.gov/pubmed/32439759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.175760
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