Polarized epidermal growth factor secretion ensures robust vulval cell fate specification in Caenorhabditis elegans

The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate. The EGF receptor in the nearest VPC sequesters the limiting EGF amounts released by the AC to prevent EGF from spreading to distal VPCs. Here, we...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Mereu, Louisa, Morf, Matthias K., Spiri, Silvan, Gutierrez, Peter, Escobar-Restrepo, Juan M., Daube, Michael, Walser, Michael, Hajnal, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286359/
https://ncbi.nlm.nih.gov/pubmed/32439759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.175760
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