Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome

Netherton syndrome is a monogenic autosomal recessive disorder primarily characterized by the detachment of the uppermost layer of the epidermis, the stratum corneum. It results from mutations in the SPINK5 gene, which codes for a kallikrein inhibitor. Uncontrolled kallikrein activity leads to prema...

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Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Muzumdar, Sukalp, Koch, Michael, Hiebert, Hayley, Bapst, Andreas, Gravina, Alessia, Bloch, Wilhelm, Beer, Hans-Dietmar, Werner, Sabine, Schäfer, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286291/
https://ncbi.nlm.nih.gov/pubmed/32457102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.042648
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