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Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome
Netherton syndrome is a monogenic autosomal recessive disorder primarily characterized by the detachment of the uppermost layer of the epidermis, the stratum corneum. It results from mutations in the SPINK5 gene, which codes for a kallikrein inhibitor. Uncontrolled kallikrein activity leads to prema...
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| Izdano u: | Dis Model Mech |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Company of Biologists Ltd
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7286291/ https://ncbi.nlm.nih.gov/pubmed/32457102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.042648 |
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