Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinocytes causes sebaceous gland enlargement and seborrhea in mi...

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Detalhes bibliográficos
Main Authors: Schäfer, Matthias, Willrodt, Ann-Helen, Kurinna, Svitlana, Link, Andrea S, Farwanah, Hany, Geusau, Alexandra, Gruber, Florian, Sorg, Olivier, Huebner, Aaron J, Roop, Dennis R, Sandhoff, Konrad, Saurat, Jean-Hilaire, Tschachler, Erwin, Schneider, Marlon R, Langbein, Lutz, Bloch, Wilhelm, Beer, Hans-Dietmar, Werner, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Backwell Publishing Ltd 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992072/
https://ncbi.nlm.nih.gov/pubmed/24503019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303281
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