iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice

BACKGROUND: Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue injury. However, the mechanisms that I/R induces I...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Du, Qiang, Luo, Jing, Yang, Mu-Qing, Liu, Quan, Heres, Caroline, Yan, Yi-He, Stolz, Donna, Geller, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285570/
https://ncbi.nlm.nih.gov/pubmed/32517688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00182-2
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