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Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD

Ever since a GGGGCC hexanucleotide repeat expansion mutation in C9ORF72 was identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), three competing but nonexclusive hypotheses to explain how this mutation causes diseases have been propos...

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Publicado en:Mol Neurodegener
Autores principales: Tang, Xiaoqiang, Toro, Arturo, T.G., Sahana, Gao, Junli, Chalk, Jessica, Oskarsson, Björn E., Zhang, Ke
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282082/
https://ncbi.nlm.nih.gov/pubmed/32513219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00383-7
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