The parkin coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

The parkin coregulated gene (PACRG), which encodes a protein of unknown function, shares a bi-directional promoter with parkin (PRKN), which encodes an E3 ubiquitin ligase. Because PRKN is important in mitochondrial quality control and protection against stress, we tested whether PACRG also affected...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Meschede, Jens, Šadić, Maria, Furthmann, Nikolas, Miedema, Tim, Sehr, Dominik A., Müller-Rischart, A. Kathrin, Bader, Verian, Berlemann, Lena A., Pilsl, Anna, Schlierf, Anita, Barkovits, Katalin, Kachholz, Barbara, Rittinger, Katrin, Ikeda, Fumiyo, Marcus, Katrin, Schaefer, Liliana, Tatzelt, Jörg, Winklhofer, Konstanze F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279956/
https://ncbi.nlm.nih.gov/pubmed/32019898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav1256
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