Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line

Mutations in PARK2 (parkin) can result in Parkinson’s disease (PD). Parkin shares a bidirectional promoter with parkin coregulated gene (PACRG) and the transcriptional start sites are separated by only ~200 bp. Bidirectionally regulated genes have been shown to function in common biological pathways...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Stephenson, Sarah E. M., Aumann, Timothy D., Taylor, Juliet M., Riseley, Jessica R., Li, Ruili, Mann, Jeffrey R., Tomas, Doris, Lockhart, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951884/
https://ncbi.nlm.nih.gov/pubmed/29760428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25766-1
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