Enhanced Sensitivity to NVP-BEZ235 by Inhibition of p62/SQSTM1 in Human Bladder Cancer KoTCC-1 Cells Both In Vitro and In Vivo

Background/Aim: The prognosis of patients with invasive bladder cancer remains poor. The objective of this study was to evaluate the efficacy of NVP-BEZ235 (NVP), a dual PI3K/mTOR inhibitor, combined with the inactivation of p62/SQSTM1 (p62) in a human bladder cancer KoTCC-1 model. Materials and Met...

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Detalhes bibliográficos
Publicado no:In Vivo
Main Authors: TAMURA, KEITA, WATANABE, KYOHEI, MATSUSHITA, YUTO, WATANABE, HIROMITSU, MOTOYAMA, DAISUKE, ITO, TOSHIKI, SUGIYAMA, TAKAYUKI, OTSUKA, ATSUSHI, MIYAKE, HIDEAKI
Formato: Artigo
Idioma:Inglês
Publicado em: International Institute of Anticancer Research 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279813/
https://ncbi.nlm.nih.gov/pubmed/32354885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/invivo.11868
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