Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells

The proteasome inhibitor bortezomib (BTZ) has emerged as an effective drug for the treatment of multiple myeloma even though many patients relapse from BTZ therapy. The present study investigated the metabolic pathways underlying the acquisition of bortezomib resistance in multiple myeloma. We used...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Tibullo, Daniele, Giallongo, Cesarina, Romano, Alessandra, Vicario, Nunzio, Barbato, Alessandro, Puglisi, Fabrizio, Parenti, Rosalba, Amorini, Angela Maria, Saab, Miriam Wissam, Tavazzi, Barbara, Mangione, Renata, Brundo, Maria Violetta, Lazzarino, Giacomo, Palumbo, Giuseppe Alberto, Li Volti, Giovanni, Di Raimondo, Francesco, Lazzarino, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277183/
https://ncbi.nlm.nih.gov/pubmed/32365811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10050696
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