Ixazomib Improves Bone Remodeling and Counteracts Sonic Hedgehog Signaling Inhibition Mediated by Myeloma Cells

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of plasma cells (PC) in the bone marrow (BM), leading to bone loss and BM failure. Osteolytic bone disease is a common manifestation observed in MM patients and represents the most severe cause of morbidity, leading...

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Main Authors: Daniele Tibullo, Anna Longo, Nunzio Vicario, Alessandra Romano, Alessandro Barbato, Michelino Di Rosa, Ignazio Barbagallo, Carmelina Daniela Anfuso, Gabriella Lupo, Rosario Gulino, Rosalba Parenti, Giovanni Li Volti, Giuseppe Alberto Palumbo, Francesco Di Raimondo, Cesarina Giallongo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-01-01
Colecção:Cancers
Assuntos:
multiple myeloma (mm)
plasma cell (pc)
ixazomib
bortezomib
mesenchymal stromal cell (msc)
sonic hedgehog (shh)
gli1
osteoclastogenesis
osteoblastogenesis
Acesso em linha:https://www.mdpi.com/2072-6694/12/2/323
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