Ixazomib Improves Bone Remodeling and Counteracts Sonic Hedgehog Signaling Inhibition Mediated by Myeloma Cells

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of plasma cells (PC) in the bone marrow (BM), leading to bone loss and BM failure. Osteolytic bone disease is a common manifestation observed in MM patients and represents the most severe cause of morbidity, leading...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Tibullo, Daniele, Longo, Anna, Vicario, Nunzio, Romano, Alessandra, Barbato, Alessandro, Di Rosa, Michelino, Barbagallo, Ignazio, Anfuso, Carmelina Daniela, Lupo, Gabriella, Gulino, Rosario, Parenti, Rosalba, Li Volti, Giovanni, Palumbo, Giuseppe Alberto, Di Raimondo, Francesco, Giallongo, Cesarina
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073172/
https://ncbi.nlm.nih.gov/pubmed/32019102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020323
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