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Quantifying genetic effects on disease mediated by assayed gene expression levels
Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs), but it remains unclear whether this overlap is driven by gene expression levels mediating genetic effects on disease. Here we introduce a new method, mediated expres...
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| 發表在: | Nat Genet |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7276299/ https://ncbi.nlm.nih.gov/pubmed/32424349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0625-2 |
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