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Quantifying genetic effects on disease mediated by assayed gene expression levels
Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs), but it remains unclear whether this overlap is driven by gene expression levels mediating genetic effects on disease. Here we introduce a new method, mediated expres...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7276299/ https://ncbi.nlm.nih.gov/pubmed/32424349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0625-2 |
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