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Distinguishing genetic correlation from causation across 52 diseases and complex traits
Mendelian randomization (MR), a method to infer causal relationships, is confounded by genetic correlations reflecting shared etiology. We developed a model in which a latent causal variable (LCV) mediates the genetic correlation; trait 1 is partially genetically causal for trait 2 if it is strongly...
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| I publikationen: | Nat Genet |
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| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684375/ https://ncbi.nlm.nih.gov/pubmed/30374074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0255-0 |
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