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Crystal structure of the LSD1/CoREST histone demethylase bound to its nucleosome substrate
LSD1 (Lysine Specific Demethylase, KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers. LSD1 demethylates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoREST repressor to act on nucleosome substrates....
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7275924/ https://ncbi.nlm.nih.gov/pubmed/32396821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.019 |
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