Loading...
Crystal structure of the LSD1/CoREST histone demethylase bound to its nucleosome substrate
LSD1 (Lysine Specific Demethylase, KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers. LSD1 demethylates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoREST repressor to act on nucleosome substrates....
Na minha lista:
| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7275924/ https://ncbi.nlm.nih.gov/pubmed/32396821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.019 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|