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Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1 – CoREST Complex
Histone demethylases LSD1 and LSD2 (KDM1A/B) catalyze the oxidative demethylation of Lys4 of histone H3. We employed molecular dynamics simulations to probe the diffusion of the oxygen substrate. Oxygen can reach the catalytic centre independently from the presence of a bound histone peptide, implyi...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059804/ https://ncbi.nlm.nih.gov/pubmed/21300290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.01.001 |
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