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LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition
The complex of lysine-specific demethylase-1 (LSD1/KDM1A) with its corepressor protein CoREST is an exceptionally relevant target for epigenetic drugs. Here, we provide insight into the local and global changes of LSD1/CoREST conformational dynamics that occur upon H3 binding on the basis of a total...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411975/ https://ncbi.nlm.nih.gov/pubmed/22802671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207892109 |
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