Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

With its noncatalytic domains, DNA-binding regions, and a catalytic core targeting the histone tails, LSD1-CoREST (lysine-specific demethylase 1; REST corepressor) is an ideal model system to study the interplay between DNA binding and histone modification in nucleosome recognition. To this end, we...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Pilotto, Simona, Speranzini, Valentina, Tortorici, Marcello, Durand, Dominique, Fish, Alexander, Valente, Sergio, Forneris, Federico, Mai, Antonello, Sixma, Titia K., Vachette, Patrice, Mattevi, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352788/
https://ncbi.nlm.nih.gov/pubmed/25730864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419468112
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