Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania

BACKGROUND: Sickle cell disease (SCD) is a blood disorder caused by a point mutation on the beta globin gene resulting in the synthesis of abnormal hemoglobin. Fetal hemoglobin (HbF) reduces disease severity, but the levels vary from one individual to another. Most research has focused on common gen...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Med Genet
Main Authors: Nkya, Siana, Mwita, Liberata, Mgaya, Josephine, Kumburu, Happiness, van Zwetselaar, Marco, Menzel, Stephan, Mazandu, Gaston Kuzamunu, Sangeda, Raphael, Chimusa, Emile, Makani, Julie
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275552/
https://ncbi.nlm.nih.gov/pubmed/32503527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-020-01059-1
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