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Ku80-targeted pH-sensitive peptide-PNA conjugates are tumor selective and sensitize cancer cells to ionizing radiation

The development of therapeutic agents that specifically target cancer cells while sparing healthy tissue could be used to enhance the efficacy of cancer therapy without increasing its toxicity. Specific targeting of cancer cells can be achieved through the use of pH-low insertion peptides (pHLIPs),...

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Publicat a:Mol Cancer Res
Autors principals: Kaplan, Alanna R., Pham, Ha, Liu, Yanfeng, Oyaghire, Stanley, Bahal, Raman, Engelman, Donald M., Glazer, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272299/
https://ncbi.nlm.nih.gov/pubmed/32098827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0661
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