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Ku80-targeted pH-sensitive peptide-PNA conjugates are tumor selective and sensitize cancer cells to ionizing radiation

The development of therapeutic agents that specifically target cancer cells while sparing healthy tissue could be used to enhance the efficacy of cancer therapy without increasing its toxicity. Specific targeting of cancer cells can be achieved through the use of pH-low insertion peptides (pHLIPs),...

詳細記述

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書誌詳細
出版年:Mol Cancer Res
主要な著者: Kaplan, Alanna R., Pham, Ha, Liu, Yanfeng, Oyaghire, Stanley, Bahal, Raman, Engelman, Donald M., Glazer, Peter M.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272299/
https://ncbi.nlm.nih.gov/pubmed/32098827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0661
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