Cdc42 mediates cancer cell chemotaxis in perineural invasion

Perineural invasion (PNI) is an ominous form of cancer progression along nerves associated with poor clinical outcome. Glial derived neurotrophic factor (GDNF) interacts with cancer cell RET receptors to enable PNI, but downstream events remain undefined. We demonstrate that GDNF leads to early acti...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Chernichenko, Natalya, Omelchenko, Tatiana, Deborde, Sylvie, Bakst, Richard, He, Shizhi, Chen, Chun-Hao, Gusain, Laxmi, Vakiani, Efsevia, Katabi, Nora, Hall, Alan, Wong, Richard J
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272295/
https://ncbi.nlm.nih.gov/pubmed/32086369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0726
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