Cdc42 mediates cancer cell chemotaxis in perineural invasion

Perineural invasion (PNI) is an ominous form of cancer progression along nerves associated with poor clinical outcome. Glial derived neurotrophic factor (GDNF) interacts with cancer cell RET receptors to enable PNI, but downstream events remain undefined. We demonstrate that GDNF leads to early acti...

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Détails bibliographiques
Publié dans:Mol Cancer Res
Auteurs principaux: Chernichenko, Natalya, Omelchenko, Tatiana, Deborde, Sylvie, Bakst, Richard, He, Shizhi, Chen, Chun-Hao, Gusain, Laxmi, Vakiani, Efsevia, Katabi, Nora, Hall, Alan, Wong, Richard J
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272295/
https://ncbi.nlm.nih.gov/pubmed/32086369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0726
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