Cdc42 mediates cancer cell chemotaxis in perineural invasion

Perineural invasion (PNI) is an ominous form of cancer progression along nerves associated with poor clinical outcome. Glial derived neurotrophic factor (GDNF) interacts with cancer cell RET receptors to enable PNI, but downstream events remain undefined. We demonstrate that GDNF leads to early acti...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Chernichenko, Natalya, Omelchenko, Tatiana, Deborde, Sylvie, Bakst, Richard, He, Shizhi, Chen, Chun-Hao, Gusain, Laxmi, Vakiani, Efsevia, Katabi, Nora, Hall, Alan, Wong, Richard J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272295/
https://ncbi.nlm.nih.gov/pubmed/32086369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0726
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