Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

The latency associated with bone metastasis emergence in castrate‐resistant prostate cancer is attributed to dormancy, a state in which cancer cells persist prior to overt lesion formation. Using single‐cell transcriptomics and ex vivo profiling, we have uncovered the critical role of tumor‐intrinsi...

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Udgivet i:EMBO Rep
Main Authors: Owen, Katie L, Gearing, Linden J, Zanker, Damien J, Brockwell, Natasha K, Khoo, Weng Hua, Roden, Daniel L, Cmero, Marek, Mangiola, Stefano, Hong, Matthew K, Spurling, Alex J, McDonald, Michelle, Chan, Chia‐Ling, Pasam, Anupama, Lyons, Ruth J, Duivenvoorden, Hendrika M, Ryan, Andrew, Butler, Lisa M, Mariadason, John M, Giang Phan, Tri, Hayes, Vanessa M, Sandhu, Shahneen, Swarbrick, Alexander, Corcoran, Niall M, Hertzog, Paul J, Croucher, Peter I, Hovens, Chris, Parker, Belinda S
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271653/
https://ncbi.nlm.nih.gov/pubmed/32314873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050162
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