Intratumoral administration of the Toll‐like receptor 7/8 agonist 3M‐052 enhances interferon‐driven tumor immunogenicity and suppresses metastatic spread in preclinical triple‐negative breast cancer

OBJECTIVES: Loss of tumor‐inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progression via decreased immunogenicity and antitumor immunity. Previous studies in murine models of triple‐negative breast cancer (TNBC) demonstrate that systemic IFN inducers ar...

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Zanker, Damien J, Spurling, Alex J, Brockwell, Natasha K, Owen, Katie L, Zakhour, Jasmine M, Robinson, Tina, Duivenvoorden, Hendrika M, Hertzog, Paul J, Mullins, Stefanie R, Wilkinson, Robert W, Parker, Belinda S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520806/
https://ncbi.nlm.nih.gov/pubmed/33005415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1177
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