Identification of PIKfyve kinase as a target in multiple myeloma

The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo patient-derived primary samples, with increased ac...

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書誌詳細
出版年:Haematologica
主要な著者: de Campos, Cecilia Bonolo, Zhu, Yuan Xiao, Sepetov, Nikolai, Romanov, Sergei, Bruins, Laura Ann, Shi, Chang-Xin, Stein, Caleb K., Petit, Joachim L., Polito, Alysia N., Sharik, Meaghen E., Meermeier, Erin W., Ahmann, Gregory J., Armenta, Ilsel D. Lopez, Kruse, Jonas, Bergsagel, P. Leif, Chesi, Marta, Meurice, Nathalie, Braggio, Esteban, Stewart, A. Keith
フォーマット: Artigo
言語:Inglês
出版事項: Ferrata Storti Foundation 2020
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271606/
https://ncbi.nlm.nih.gov/pubmed/31582538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.222729
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