Identification of PIKfyve kinase as a target in multiple myeloma

The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo patient-derived primary samples, with increased ac...

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Publicado no:Haematologica
Main Authors: de Campos, Cecilia Bonolo, Zhu, Yuan Xiao, Sepetov, Nikolai, Romanov, Sergei, Bruins, Laura Ann, Shi, Chang-Xin, Stein, Caleb K., Petit, Joachim L., Polito, Alysia N., Sharik, Meaghen E., Meermeier, Erin W., Ahmann, Gregory J., Armenta, Ilsel D. Lopez, Kruse, Jonas, Bergsagel, P. Leif, Chesi, Marta, Meurice, Nathalie, Braggio, Esteban, Stewart, A. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271606/
https://ncbi.nlm.nih.gov/pubmed/31582538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.222729
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