A robust LC–MS/MS method for amikacin: application to cellular uptake and pharmacokinetic studies

BACKGROUND: Aminoglycosides are last-resort antibiotics for bacterial infections due to concerns of nephrotoxicity. A robust method is needed to correlate the magnitude of drug accumulation in the kidneys and the onset of nephrotoxicity. MATERIALS & METHODS: A LC–MS/MS assay was developed, circu...

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Detalhes bibliográficos
Publicado no:Bioanalysis
Main Authors: Chan, Katrina, Wang, Weiqun, Ledesma, Kimberly R, Yin, Taijun, Tam, Vincent H
Formato: Artigo
Idioma:Inglês
Publicado em: Newlands Press Ltd 2020
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270885/
https://ncbi.nlm.nih.gov/pubmed/32343148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/bio-2020-0007
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