Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: Application to pharmacokinetic and disposition studies

The purpose of this study was to develop a simultaneous, sensitive and reproducible UPLC-MS/MS method to quantify maackiain and its phase II metabolites, maackiain-sulfate (M-7-S) and maackiain-glucuronide (M-7-G). A Waters BEH C(18) column was used with acetonitrile/water as mobile phases. Analysis...

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Bibliografische gegevens
Hoofdauteurs: Gao, Song, Yang, Zhen, Yin, Taijun, You, Ming, Hu, Ming
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085908/
https://ncbi.nlm.nih.gov/pubmed/21349678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2011.01.015
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