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Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies

The aim of this study is to develop a sensitive UPLC-MS/MS method to quantify columbin in biological sample. Chromatographic separation was accomplished using Waters UPLC BEH C(18) column with acetonitrile and 0.1% of formic acid in water as the mobile phases. The mass analysis was performed on an A...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Yang, Guangyi, Gao, Song, Sun, Rongjin, Yin, Taijun, Hu, Ming
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659646/
https://ncbi.nlm.nih.gov/pubmed/26295697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2015.07.030
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