Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-type 12-Lipoxygenase

Human platelet hALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and stereo-specificities (i.e., 100 +/− 5% of the...

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Udgivet i:Biochemistry
Main Authors: Aleem, Ansari Mukhtar, Tsai, Wan-Chen, Tena, Jennyfer, Alvarez, Gabriella, Deschamps, Joshua, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Holman, Theodore
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270147/
https://ncbi.nlm.nih.gov/pubmed/30565457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01167
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