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Enzymatic studies of isoflavonoids as selective and potent inhibitors of human leukocyte 5-lipoxygenase

Continuing our search to find more potent and selective 5-LOX inhibitors, we present now the enzymatic evaluation of seventeen isoflavones (IR) and nine isoflavans (HIR), and their in vitro and in cellulo potency against human leukocyte 5-LOX. Of the 26 compounds tested, 10 isoflavones and 9 isoflav...

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Detalles Bibliográficos
Publicado en:Chem Biol Drug Des
Main Authors: Mascayano, Carolina, Espinosa, Victoria, Sepúlveda-Boza, Silvia, Hoobler, Eric K., Perry, Steve, Diaz, Giovanni, Holman, Theodore R.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270146/
https://ncbi.nlm.nih.gov/pubmed/25359714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12469
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