Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes

STAG2 encodes a cohesin component and is frequently mutated in myeloid neoplasms, showing highly significant co-mutation patterns with other drivers, including RUNX1. However, the molecular basis of cohesin-mutated leukemogenesis remains poorly understood. Here we show a critical role of an interpla...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Ochi, Yotaro, Kon, Ayana, Sakata, Toyonori, Nakagawa, Masahiro M, Nakazawa, Naotaka, Kakuta, Masanori, Kataoka, Keisuke, Koseki, Haruhiko, Nakayama, Manabu, Morishita, Daisuke, Tsuruyama, Tatsuaki, Saiki, Ryunosuke, Yoda, Akinori, Okuda, Rurika, Yoshizato, Tetsuichi, Yoshida, Kenichi, Shiozawa, Yusuke, Nannya, Yasuhito, Kotani, Shinichi, Kogure, Yasunori, Kakiuchi, Nobuyuki, Nishimura, Tomomi, Makishima, Hideki, Malcovati, Luca, Yokoyama, Akihiko, Takeuchi, Kengo, Sugihara, Eiji, Sato, Taka-aki, Sanada, Masashi, Takaori-Kondo, Akifumi, Cazzola, Mario, Kengaku, Mineko, Miyano, Satoru, Shirahige, Katsuhiko, Suzuki, Hiroshi I, Ogawa, Seishi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269820/
https://ncbi.nlm.nih.gov/pubmed/32249213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0982
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