Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes

STAG2 encodes a cohesin component and is frequently mutated in myeloid neoplasms, showing highly significant co-mutation patterns with other drivers, including RUNX1. However, the molecular basis of cohesin-mutated leukemogenesis remains poorly understood. Here we show a critical role of an interpla...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cancer Discov
Κύριοι συγγραφείς: Ochi, Yotaro, Kon, Ayana, Sakata, Toyonori, Nakagawa, Masahiro M, Nakazawa, Naotaka, Kakuta, Masanori, Kataoka, Keisuke, Koseki, Haruhiko, Nakayama, Manabu, Morishita, Daisuke, Tsuruyama, Tatsuaki, Saiki, Ryunosuke, Yoda, Akinori, Okuda, Rurika, Yoshizato, Tetsuichi, Yoshida, Kenichi, Shiozawa, Yusuke, Nannya, Yasuhito, Kotani, Shinichi, Kogure, Yasunori, Kakiuchi, Nobuyuki, Nishimura, Tomomi, Makishima, Hideki, Malcovati, Luca, Yokoyama, Akihiko, Takeuchi, Kengo, Sugihara, Eiji, Sato, Taka-aki, Sanada, Masashi, Takaori-Kondo, Akifumi, Cazzola, Mario, Kengaku, Mineko, Miyano, Satoru, Shirahige, Katsuhiko, Suzuki, Hiroshi I, Ogawa, Seishi
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2020
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269820/
https://ncbi.nlm.nih.gov/pubmed/32249213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0982
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